Formulation and Evaluation of Timolol Maleate Proniosomal Gel for Ocular Drug Delivery
نویسندگان
چکیده
Introduction: The objective of this task is to succeed with the trial an ocularly efficient Timolol maleate formulation produced from prolonged proniosomal gel niosomes get significant therapy for glaucoma. Methods: Cholesterol, Lecithin, Span 60, Brij 72, and Tween 80 in various concentrations were used create loaded derived utilizing phase coacervation method. Found on these outcomes entrapment efficiency in-vitro release, optimised batch gel-produced was chosen. By spreading proniosomes in-situ gelling method, timolol gel-derived created. Fourier transforms infrared spectroscopy (FTIR) experiments confirmed each interaction study. Wetting agent additive effects along drug release manner based investigated. quantities a technique, by dispersing Results: FTIR analyses revealed no signs between medicine excipients, indicating that they are compatible. At end 12 hr, formulations T2 T10 had 99.98 percent 99.90 respectively. Conclusion: Starting findings secured, it can be closed one might satisfactory alternative conventional eye drops as exhibited elevated penetrability sustained-release actions.
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ژورنال
عنوان ژورنال: International journal of pharmaceutical investigation
سال: 2022
ISSN: ['2230-9713', '2230-973X']
DOI: https://doi.org/10.5530/ijpi.2022.3.65